Disease gene prioritization by integrating tissue-specific molecular networks using a robust multi-network model.

ABSTRACT:

Background

Accurately prioritizing candidate disease genes is an important and challenging problem. Various network-based methods have been developed to predict potential disease genes by utilizing the disease similarity network and molecular networks such as protein interaction or gene co-expression networks. Although successful, a common limitation of the existing methods is that they assume all diseases share the same molecular network and a single generic molecular network is used to predict candidate genes for all diseases. However, different diseases tend to manifest in different tissues, and the molecular networks in different tissues are usually different. An ideal method should be able to incorporate tissue-specific molecular networks for different diseases.

Results

SUBMITTER: Ni J 

PROVIDER: S-EPMC5103411 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature