Characterization of exosomal release in bovine endometrial intercaruncular stromal cells.

ABSTRACT:

Background

Cell-to-cell communication between the blastocyst and endometrium is critical for implantation. In recent years, evidence has emerged from studies in humans and several other animal species that exosomes are secreted from the endometrium and trophoblast cells and may play an important role in cell-to-cell communication maternal-fetal interface during early pregnancy. Exosomes are stable extracellular lipid bilayer vesicles that encapsulate proteins, miRNAs, and mRNAs, with the ability to deliver their cargo to near and distant sites, altering cellular function(s). Furthermore, the exosomal cargo can be altered in response to environmental cues (e.g. hypoxia). The current study aims to develop an in vitro system to evaluate maternal-embryo interactions via exosomes (and e

SUBMITTER: Koh YQ 

PROVIDER: S-EPMC5103490 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature