Anterior insula volume and guilt: neurobehavioral markers of recurrence after early childhood major depressive disorder.

ABSTRACT:

Importance

This is the first study to date to examine volumetric alterations in the anterior insula (AI) as a potential biomarker for the course of childhood major depressive disorder (MDD).

Objectives

To examine whether children with a history of preschool-onset (PO) MDD show reduced AI volume, whether a specific symptom of PO MDD (pathological guilt) is related to AI volume reduction (given the known relationship between AI and guilt processing), and whether AI volumes predict subsequent likelihood of having an episode of MDD.

Design, setting, and participants

In a prospective longitudinal study, 306 children (age range, 3.00-5.11 years) and caregivers completed DSM diagnostic assessments at 6 annual time points during 10 years as part of the Preschool Depression St

SUBMITTER: Belden AC 

PROVIDER: S-EPMC5103694 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature