Genetic Variants Associated With Atrial Fibrillation and PR Interval Following Cardiac Surgery.

ABSTRACT:

Objective

The authors hypothesized that genetic association between atrial fibrillation (AF)-associated and PR-associated genetic loci was biologically mediated through slower conduction velocities for some or all of these loci.

Design

Prospectively collected cohort study.

Setting

Single tertiary care university hospital.

Participants

A total of 1227 Caucasian patients who underwent coronary artery bypass grafting (CABG).

Interventions

A total of 677 single nucleotide polymorphisms previously associated with ambulatory AF or PR interval were tested for association with postoperative atrial fibrillation (poAF) and preoperative PR interval, maximum PR interval, maximum change in PR interval, and maximum change in PR interval from preoperative PR interval.<

SUBMITTER: Sigurdsson MI 

PROVIDER: S-EPMC5103707 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature