Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis.

ABSTRACT: One of the primary targets of the clinical treatment of ulcerative colitis (UC) is to repair the damaged colonic mucosa. Mesenchymal stem cells (MSCs) have therapeutic potential in regenerative medicine due to their differentiation capacity and their secretion of numerous bioactive molecules. The present study describes a clinical trial (trial registration no. NCT01221428) investigating the safety and therapeutic effect of MSCs derived from human umbilical cord on moderate to severe UC. Thirty-four patients with UC were included in group I and treated with MSC infusion in addition to the base treatment, and thirty-six patients were in group II and treated with normal saline in addition to the base treatment. One month after therapy, 30/36 patients in group I showed goo

SUBMITTER: Hu J 

PROVIDER: S-EPMC5103734 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature