Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum.

ABSTRACT:

Background

Loss-of-function null mutations R501X and 2282del4 in the skin barrier gene, filaggrin (FLG), represent the most replicated genetic risk factors for atopic dermatitis (AD). Associations have not been reported in African ancestry populations. Atopic dermatitis eczema herpeticum (ADEH) is a rare but serious complication of AD resulting from disseminated cutaneous herpes simplex virus infections.

Objective

We aimed to determine whether FLG polymorphisms contribute to ADEH susceptibility.

Methods

Two common loss-of-function mutations plus 9 FLG single nucleotide polymorphisms were genotyped in 278 European American patients with AD, of whom 112 had ADEH, and 157 nonatopic controls. Replication was performed on 339 African American subjects.

Results

Signi

SUBMITTER: Gao PS 

PROVIDER: S-EPMC5103856 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature