Blood-brain barrier integrity, intrathecal immunoactivation, and neuronal injury in HIV.

ABSTRACT:

Objective

Although blood-brain barrier (BBB) impairment has been reported in HIV-infected individuals, characterization of this impairment has not been clearly defined.

Methods

BBB integrity was measured by CSF/plasma albumin ratio in this cross-sectional study of 631 HIV-infected individuals and 71 controls. We also analyzed CSF and blood HIV RNA and neopterin, CSF leukocyte count, and neurofilament light chain protein (NFL) concentrations. The HIV-infected participants included untreated neuroasymptomatic patients, patients with untreated HIV-associated dementia (HAD), and participants on suppressive antiretroviral treatment (ART).

Results

The albumin ratio was significantly increased in patients with HAD compared to all other groups. There were no significant diffe

SUBMITTER: Anesten B 

PROVIDER: S-EPMC5104266 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature