Transcriptome Dynamics and Potential Roles of Sox6 in the Postnatal Heart.

ABSTRACT: The postnatal heart undergoes highly coordinated developmental processes culminating in the complex physiologic properties of the adult heart. The molecular mechanisms of postnatal heart development remain largely unexplored despite their important clinical implications. To gain an integrated view of the dynamic changes in gene expression during postnatal heart development at the organ level, time-series transcriptome analyses of the postnatal hearts of neonatal through adult mice (P1, P7, P14, P30, and P60) were performed using a newly developed bioinformatics pipeline. We identified functional gene clusters by principal component analysis with self-organizing map clustering which revealed organized, discrete gene expression patterns corresponding to biological functions associated with t

SUBMITTER: An CI 

PROVIDER: S-EPMC5104335 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature