The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice.

ABSTRACT: Nutrition influences skin structure; however, a systematic investigation into how energy and macronutrients (protein, carbohydrate and fat) affects the skin has yet to be conducted. We evaluated the associations between macronutrients, energy intake and skin structure in mice fed 25 experimental diets and a control diet for 15 months using the Geometric Framework, a novel method of nutritional analysis. Skin structure was associated with the ratio of dietary macronutrients eaten, not energy intake, and the nature of the effect differed between the sexes. In males, skin structure was primarily associated with protein intake, whereas in females carbohydrate intake was the primary correlate. In both sexes, the dermis and subcutaneous fat thicknesses were inversely proportional. Subcutaneous f

SUBMITTER: Hew J 

PROVIDER: S-EPMC5104383 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature