Systematic Design of a Metal Ion Biosensor: A Multi-Objective Optimization Approach.

ABSTRACT: With the recent industrial expansion, heavy metals and other pollutants have increasingly contaminated our living surroundings. Heavy metals, being non-degradable, tend to accumulate in the food chain, resulting in potentially damaging toxicity to organisms. Thus, techniques to detect metal ions have gradually begun to receive attention. Recent progress in research on synthetic biology offers an alternative means for metal ion detection via the help of promoter elements derived from microorganisms. To make the design easier, it is necessary to develop a systemic design method for evaluating and selecting adequate components to achieve a desired detection performance. A multi-objective (MO) H2/H∞ performance criterion is derived here for design specifications of a metal ion biosensor to ach

SUBMITTER: Hsu CY 

PROVIDER: S-EPMC5104392 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature