The Potential Use of Salivary miRNAs as Promising Biomarkers for Detection of Cancer: A Meta-Analysis.

ABSTRACT:

Background

Accumulating evidence has demonstrated that microRNAs (miRNAs) could serve as promising molecular biomarkers for cancer detection. This study aims to systematically assess the diagnostic performance of salivary miRNAs in detection of cancer through a comprehensive meta-analysis.

Methods

Eligible studies were identified using PubMed and other computerized databases up to October 31, 2015, supplemented by a manual search of references from retrieved articles. The pooled sensitivity, specificity, and other measurements of accuracy of salivary miRNAs in the diagnosis of cancer were analyzed using the bivariate binomial mixed model.

Results

Seventeen studies from 8 articles with 694 subjects were included in this meta-analysis. All studies have a relatively high

SUBMITTER: Ding Y 

PROVIDER: S-EPMC5104484 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature