Achieving regio- and stereo-control in the fluorination of aziridines under acidic conditions.

ABSTRACT: We developed an efficient fluorination protocol that converts easily accessible aziridines into β-fluoroamines, which are important motifs in biologically active molecules. In contrast with traditional fluorination approaches, DMPU-HF has shown both higher reactivity and regioselectivity and good functional group tolerance; thus, a wide scope of β-fluoroamines can now be accessed conveniently. The stereochemical behavior of the ring opening depends on the substitution pattern of the aziridine substrate.

SUBMITTER: Okoromoba OE 

PROVIDER: S-EPMC5104567 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature