Obstructive sleep apnea and Fuhrman grade in patients with clear cell renal cell carcinoma treated surgically.

ABSTRACT:

Purpose

To assess the association between obstructive sleep apnea (OSA) and Fuhrman grade in patients with clear cell renal cell carcinoma (ccRCC). As secondary endpoints, we studied its association with tumor size, metastasis-free survival (MFS) and cancer-specific survival (CSS).

Methods

We reviewed the databases of two tertiary care centers, identifying 2579 patients who underwent partial or radical nephrectomy for ccRCC between 1991 and 2014. Descriptive statistics were used to compare pathologic variables between patients with and without OSA. Linear and logistic regression models were used to assess the association of OSA with Fuhrman grade and tumor size. A Cox proportional hazards model was used to determine OSA association with MFS and CSS. A pathway analysis was pe

SUBMITTER: Vilaseca A 

PROVIDER: S-EPMC5104663 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature