Outcome of ovarian cancer after breast cancer in BRCA1 and BRCA2 mutation carriers.

ABSTRACT:

Background

It is unknown whether a history of breast cancer (BC) affects the outcome of BRCA1/2-associated epithelial ovarian cancer (EOC). This was investigated in the current analysis.

Methods

We included 386 BRCA1/2-associated EOC patients diagnosed between 1980 and 2015. Progression-free survival (PFS), progression-free interval (PFI), overall survival (OS) and ovarian cancer-specific survival (OCSS) were compared between EOC patients with and without previous BC.

Results

BRCA-associated EOC patients with, vs without, a BC history had a significantly worse PFS and PFI (multivariate hazard ratio (HR_mult) 1.47; 95% confidence interval (CI) 1.03-2.08 and HR_mult 1.43; 95% CI 1.01-2.03), and a non-significantly worse OS (HR_mult 1.15; 95

SUBMITTER: Zaaijer LH 

PROVIDER: S-EPMC5104898 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature