Long-term evolution of multiple sclerosis disability in the treatment era.

ABSTRACT:

Objective

To characterize the accrual of long-term disability in a cohort of actively treated multiple sclerosis (MS) patients and to assess whether clinical and magnetic resonance imaging (MRI) data used in clinical trials have long-term prognostic value.

Methods

This is a prospective study of 517 actively managed MS patients enrolled at a single center.

Results

More than 91% of patients were retained, with data ascertained up to 10 years after the baseline visit. At this last assessment, neurologic disability as measured by the Expanded Disability Status Scale (EDSS) was stable or improved compared to baseline in 41% of patients. Subjects with no evidence of disease activity (NEDA) by clinical and MRI criteria during the first 2 years had long-term outcomes that wer

SUBMITTER: University of California, San Francisco MS-EPIC Team: 

PROVIDER: S-EPMC5105678 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature