Reducing HIV infection in people who inject drugs is impossible without targeting recently-infected subjects.

ABSTRACT:

Objective

Although our understanding of viral transmission among people who inject drugs (PWID) has improved, we still know little about when and how many times each injector transmits HIV throughout the duration of infection. We describe HIV dynamics in PWID to evaluate which preventive strategies can be efficient.

Design

Due to the notably scarce interventions, HIV-1 spread explosively in Russia and Ukraine in 1990s. By studying this epidemic between 1995 and 2005, we characterized naturally occurring transmission dynamics of HIV among PWID.

Method

We combined publicly available HIV pol and env sequences with prevalence estimates from Russia and Ukraine under an evolutionary epidemiology framework to characterize HIV transmissibility between PWID. We then constructe

SUBMITTER: Vasylyeva TI 

PROVIDER: S-EPMC5106086 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature