Use of CA-125 Tests and Computed Tomographic Scans for Surveillance in Ovarian Cancer.

ABSTRACT:

Importance

A 2009 randomized clinical trial demonstrated that using cancer antigen 125 (CA-125) tests for routine surveillance in ovarian cancer increases the use of chemotherapy and decreases patients' quality of life without improving survival, compared with clinical observation. The Society of Gynecologic Oncology guidelines categorize CA-125 testing as optional and discourage the use of radiographic imaging for routine surveillance. To date, few studies have examined the use of CA-125 tests in clinical practice.

Objectives

To examine the use of CA-125 tests and computed tomographic (CT) scans in clinical practice before and after the 2009 randomized clinical trial and to estimate the economic effect of surveillance testing.

Design, setting, and participants

A pros

SUBMITTER: Esselen KM 

PROVIDER: S-EPMC5106306 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature