High levels of pre-treatment HIV drug resistance and treatment failure in Nigerian children.

ABSTRACT:

Introduction

Pre-treatment HIV drug resistance (PDR) is an increasing problem in sub-Saharan Africa. Children are an especially vulnerable population to develop PDR given that paediatric second-line treatment options are limited. Although monitoring of PDR is important, data on the paediatric prevalence in sub-Saharan Africa and its consequences for treatment outcomes are scarce. We designed a prospective paediatric cohort study to document the prevalence of PDR and its effect on subsequent treatment failure in Nigeria, the country with the second highest number of HIV-infected children in the world.

Methods

HIV-1-infected children ≤12 years, who had not been exposed to drugs for the prevention of mother-to-child transmission (PMTCT), were enrolled between 2012 and 2013, and

SUBMITTER: Boerma RS 

PROVIDER: S-EPMC5106466 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature