Refractory septic shock in children: a European Society of Paediatric and Neonatal Intensive Care definition.

ABSTRACT:

Purpose

Although overall paediatric septic shock mortality is decreasing, refractory septic shock (RSS) is still associated with high mortality. A definition for RSS is urgently needed to facilitate earlier identification and treatment. We aim to establish a European society of paediatric and neonatal intensive care (ESPNIC) experts' definition of paediatric RSS.

Methods

We conducted a two-round Delphi study followed by an observational multicentre retrospective study. One hundred and fourteen paediatric intensivists answered a clinical case-based, two-round Delphi survey, identifying clinical items consistent with RSS. Multivariate analysis of these items in a development single-centre cohort (70 patients, 30 % mortality) facilitated development of RSS definitions based on

SUBMITTER: Morin L 

PROVIDER: S-EPMC5106490 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature