Bordetella pertussis Infection in South African HIV-Infected and HIV-Uninfected Mother-Infant Dyads: A Longitudinal Cohort Study.

ABSTRACT:

Background

 There is a paucity of data regarding the burden of Bordetella pertussis in African women and young infants, and particularly the impact of maternal human immunodeficiency virus (HIV) infection thereon. We performed a retrospective analysis of respiratory illness samples from longitudinal cohorts of HIV-uninfected and HIV-infected women and their infants to evaluate the burden of pertussis illness in a black-African community.

Methods

 The women were followed up for respiratory illness from midpregnancy and together with their infants until 24 weeks postpartum. Respiratory samples obtained at the time of illness visits were tested for B. pertussis by polymerase chain reaction (PCR).

Results

 The study included 194 HIV-infected and 1060 HIV-uninfected women,

SUBMITTER: Nunes MC 

PROVIDER: S-EPMC5106617 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature