The Burden of Pertussis Hospitalization in HIV-Exposed and HIV-Unexposed South African Infants.

ABSTRACT:

Background

 There are limited data on pertussis in African children, including among human immunodeficiency virus (HIV)-exposed infants. We conducted population-based hospital surveillance to determine the incidence and clinical presentation of Bordetella pertussis-associated hospitalization in perinatal HIV-exposed and -unexposed infants.

Methods

 Children <12 months of age hospitalized with any sign or symptom of respiratory illness (including suspected sepsis or apnea in neonates) were enrolled from 1 January 2015 to 31 December 2015. Detailed clinical and demographic information was recorded and respiratory samples were tested by polymerase chain reaction (PCR).

Results

 The overall B. pertussis PCR positivity was 2.3% (42/1839), of which 86% (n = 36) occurred in

SUBMITTER: Soofie N 

PROVIDER: S-EPMC5106620 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature