Forecasting Epidemiological Consequences of Maternal Immunization.

ABSTRACT:

Background

 The increase in the incidence of whooping cough (pertussis) in many countries with high vaccination coverage is alarming. Maternal pertussis immunization has been proposed as an effective means of protecting newborns during the interval between birth and the first routine dose. However, there are concerns regarding potential interference between maternal antibodies and the immune response elicited by the routine schedule, with possible long-term population-level effects.

Methods

 We formulated a transmission model comprising both primary routine and maternal immunization. This model was examined to evaluate the long-term epidemiological effects of routine and maternal immunization, together with consequences of potential immune interference scenarios.

Results<

SUBMITTER: Bento AI 

PROVIDER: S-EPMC5106624 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature