CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease.

ABSTRACT:

Introduction

Alzheimer's disease (AD) and Parkinson's disease (PD) involve tau pathology. Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood.

Methods

Tau efflux from the brain to the blood was evaluated by administering radioactively labeled and unlabeled tau intracerebroventricularly in wild-type and tau knock-out mice, respectively. Central nervous system (CNS)-derived tau in L1CAM-containing exosomes was further characterized extensively in human plasma, including by single molecule array technology with 303 subjects.

Results

The efflux of Tau, including a fraction via CNS-derived L1CAM exosomes, was observed in mice. In human plasma, tau was explicitly identified within L1CAM exosomes. In contrast to AD patients, L

SUBMITTER: Shi M 

PROVIDER: S-EPMC5107127 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature