Differential brain network activity across mood states in bipolar disorder.

ABSTRACT:

Background

This study aimed to identify how the activity of large-scale brain networks differs between mood states in bipolar disorder. The authors measured spontaneous brain activity in subjects with bipolar disorder in mania and euthymia and compared these states to a healthy comparison population.

Methods

23 subjects with bipolar disorder type I in a manic episode, 24 euthymic bipolar I subjects, and 23 matched healthy comparison (HC) subjects underwent resting state fMRI scans. Using an existing parcellation of the whole brain, we measured functional connectivity between brain regions and identified significant differences between groups.

Results

In unbiased whole-brain analyses, functional connectivity between parietal, occipital, and frontal nodes within the dor

SUBMITTER: Brady RO 

PROVIDER: S-EPMC5107137 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature