Improved facial nerve identification during parotidectomy with fluorescently labeled peptide.

ABSTRACT:

Objectives/hypothesis

Additional intraoperative guidance could reduce the risk of iatrogenic injury during parotid gland cancer surgery. We evaluated the intraoperative use of fluorescently labeled nerve binding peptide NP41 to aid facial nerve identification and preservation during parotidectomy in an orthotopic model of murine parotid gland cancer. We also quantified the accuracy of intraoperative nerve detection for surface and buried nerves in the head and neck with NP41 versus white light (WL) alone.

Study design

Twenty-eight mice underwent parotid gland cancer surgeries with additional fluorescence (FL) guidance versus WL reflectance (WLR) alone. Eight mice were used for additional nerve-imaging experiments.

Methods

Twenty-eight parotid tumor-bearing mice underw

SUBMITTER: Hussain T 

PROVIDER: S-EPMC5107163 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature