Bridgehead-Substituted Triptycenes for Discovery of Nucleic Acid Junction Binders.

ABSTRACT: Recently, the utility of triptycene as a scaffold for targeting nucleic acid three-way junctions was demonstrated. A rapid, efficient route for the synthesis of bridgehead-substituted triptycenes is reported, in addition to solid-phase diversification to a new class of triptycene peptides. The triptycene peptides were evaluated for binding to a d(CAG)·(CTG) repeat DNA junction exhibiting potent affinities. The bridgehead-substituted triptycenes provide new building blocks for rapid access to diverse triptycene ligands with novel architectures.

SUBMITTER: Barros SA 

PROVIDER: S-EPMC5107256 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature