Vitamin B₁₂ deficiency results in severe oxidative stress, leading to memory retention impairment in Caenorhabditis elegans.

ABSTRACT: Oxidative stress is implicated in various human diseases and conditions, such as a neurodegeneration, which is the major symptom of vitamin B₁₂ deficiency, although the underlying disease mechanisms associated with vitamin B₁₂ deficiency are poorly understood. Vitamin B₁₂ deficiency was found to significantly increase cellular H₂O₂ and NO content in Caenorhabditis elegans and significantly decrease low molecular antioxidant [reduced glutathione (GSH) and L-ascorbic acid] levels and antioxidant enzyme (superoxide dismutase and catalase) activities, indicating that vitamin B₁₂ deficiency induces severe oxidative stress leading to oxidative damage of various cellular components in worms. An NaCl chemotaxis associative learning

SUBMITTER: Bito T 

PROVIDER: S-EPMC5107735 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature