Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ^12,14-Prostaglandin J₂ (15d-PGJ₂) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4⁺CD25^-FOXP3⁺ Cells.

ABSTRACT: The prostaglandin, 15-deoxy Δ^12,14-prostaglandin J₂ (15d-PGJ₂), is a lipid mediator that plays an important role in the control of chronic inflammatory disease. However, the role of prostanoid in rheumatoid arthritis (RA) is not well determined. We demonstrated the therapeutic effect of 15d-PGJ₂ in an experimental model of arthritis. Daily administration of 15d-PGJ₂ attenuated the severity of CIA, reducing the clinical score, pain, and edema. 15d-PGJ₂ treatment was associated with a marked reduction in joint levels of proinflammatory cytokines. Although the mRNA expression of ROR-γt was profoundly reduced, FOXP3 was enhanced in draining lymph node cells from 15d-PGJ₂-treated arthritic mice. The specific and

SUBMITTER: Carregaro V 

PROVIDER: S-EPMC5107840 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature