Vaginal Lactoferrin Modulates PGE₂, MMP-9, MMP-2, and TIMP-1 Amniotic Fluid Concentrations.

ABSTRACT: Inflammation plays an important role in pregnancy, and cytokine and matrix metalloproteases (MMPs) imbalance has been associated with premature rupture of membranes and increased risk of preterm delivery. Previous studies have demonstrated that lactoferrin (LF), an iron-binding protein with anti-inflammatory properties, is able to decrease amniotic fluid (AF) levels of IL-6. Therefore, we aimed to evaluate the effect of vaginal LF administration on amniotic fluid PGE₂ level and MMP-TIMP system in women undergoing genetic amniocentesis. One hundred and eleven women were randomly divided into controls (n = 57) or treated with LF 4 hours before amniocentesis (n = 54). Amniotic fluid PGE₂, active MMP-9 and MMP-2, and TIMP-1 and TIMP-2 concentrations were det

SUBMITTER: Trentini A 

PROVIDER: S-EPMC5107848 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature