Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain.

ABSTRACT: The development of neuropathic pain involves persistent changes in signalling within pain pathways. Reduced inhibitory signalling in the spinal cord following nerve-injury has been used to explain sensory signs of neuropathic pain but specific circuits that lose inhibitory input have not been identified. This study shows a specific population of spinal cord interneurons, radial neurons, lose glycinergic inhibitory input in a rat partial sciatic nerve ligation (PNL) model of neuropathic pain. Radial neurons are excitatory neurons located in lamina II of the dorsal horn, and are readily identified by their morphology. The amplitude of electrically-evoked glycinergic inhibitory post-synaptic currents (eIPSCs) was greatly reduced in radial neurons following nerve-injury associated with increas

SUBMITTER: Imlach WL 

PROVIDER: S-EPMC5107903 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature