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Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle.

ABSTRACT: Two new grayanoids, rhodomollin A (1) and rhodomollin B (2), possessing an unprecedented D-homo grayanane carbon skeleton, were isolated from the fruits of Rhododendron molle. The structures of 1 and 2 were fully characterized using a combination of spectroscopic analyses and X-ray crystallography. Rhodomollin B (2) exhibited modest activity against influenza virus A/95-359, with an IC₅₀ value of 19.24 μM.

SUBMITTER: Li Y

PROVIDER: S-EPMC5107939 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle.

Li Yong Y Liu Yun-Bao YB Yan Hui-Min HM Liu Yang-Lan YL Li Yu-Huan YH Lv Hai-Ning HN Ma Shuang-Gang SG Qu Jing J Yu Shi-Shan SS

Scientific reports 20161114

Two new grayanoids, rhodomollin A (1) and rhodomollin B (2), possessing an unprecedented D-homo grayanane carbon skeleton, were isolated from the fruits of Rhododendron molle. The structures of 1 and 2 were fully characterized using a combination of spectroscopic analyses and X-ray crystallography. Rhodomollin B (2) exhibited modest activity against influenza virus A/95-359, with an IC50 value of 19.24 μM. ...[more]

PMID: 27841292

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