Association of CD59 and CFH polymorphisms with acute anterior uveitis in Chinese population.

ABSTRACT: PurposeCD59 complement regulator and complement factor H (CFH) have important roles in complement activation pathways, which are known to affect the development of uveitis. The present study was performed to investigate whether an association exists between CD59 and CFH genetic polymorphisms and acute anterior uveitis (AAU).MethodsA total of 600 individuals (300 patients diagnosed with AAU and 300 healthy controls) were recruited for this case-control study. Five single-nucleotide polymorphisms (SNPs) in CD59 (rs831626, rs12272807, rs831625, rs11585, and rs12576440) and CFH-rs1065489 were genotyped using Sequenom MassARRAY technology. Allele and genotype frequencies were statistically compared between patients and controls using χ² test. Analyses were stratified for gender, huma

SUBMITTER: Wang QF 

PROVIDER: S-EPMC5108010 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature