Incidence, Severity, and Outcomes of AKI Associated with Dual Renin-Angiotensin System Blockade.

ABSTRACT:

Background and objectives

The benefit of dual blockade of the renin-angiotensin system is limited by adverse effects. We performed a secondary analysis of the Veterans Affairs Nephropathy in Diabetes (VA NEPHRON-D) Study to describe the effect of increased intensity of renin-angiotensin system blockade on the incidence, risk factors, and outcomes of AKI.

Design, setting, participants, & measurements

In the VA NEPHRON-D Study, we randomized 1148 veterans receiving outpatient care with type 2 diabetes mellitus, eGFR of between 30 and 89.9 ml/min per 1.73 m², and urinary albumin excretion of at least 300 μg/mg creatinine (or a urinary total protein of at least 0.5 mg/mg creatinine) to either combination therapy with losartan and lisinopril or monotherapy with losarta

SUBMITTER: Palevsky PM 

PROVIDER: S-EPMC5108193 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature