CD8⁺ T Lymphocyte Self-Renewal during Effector Cell Determination.

ABSTRACT: Selected CD8⁺ T cells must divide, produce differentiated effector cells, and self-renew, often repeatedly. We now show that silencing expression of the transcription factor TCF1 marks loss of self-renewal by determined effector cells and that this requires cell division. In acute infections, the first three CD8⁺ T cell divisions produce daughter cells with unequal proliferative signaling but uniform maintenance of TCF1 expression. The more quiescent initial daughter cells resemble canonical central memory cells. The more proliferative, effector-prone cells from initial divisions can subsequently undergo division-dependent production of a TCF1-negative effector daughter cell along with a self-renewing TCF1-positive daughter cell, the latter also contributing to the me

SUBMITTER: Lin WW 

PROVIDER: S-EPMC5108530 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature