Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study.

ABSTRACT:

Background

In vitro, disulfiram activated HIV transcription in a primary T-cell model of HIV latency and in a pilot clinical study increased plasma HIV RNA in individuals with adequate drug exposure. We assessed the effect of disulfiram on HIV transcription in a dose-escalation study.

Methods

In this prospective dose-escalation study, to optimise disulfiram exposure we included adults with HIV on suppressive antiretroviral therapy, with plasma HIV RNA of less than 50 copies per mL and a CD4 cell count greater than 350 cells per μL. Participants were allocated sequentially to one of three dosing groups (500 mg, 1000 mg, and 2000 mg) and received disulfiram daily for 3 days. Only the staff who did laboratory assays were masked to group assignment. The primary endpoint was chan

SUBMITTER: Elliott JH 

PROVIDER: S-EPMC5108570 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature