An Exploratory Association Study of Alcohol Use Disorder and DNA Methylation.

ABSTRACT:

Background

Epigenetic factors, including DNA methylation, play an important role in the etiology of alcohol use disorders (AUDs). Noncandidate-based methylome-wide studies leveraging multiple tissue types are needed in order to identify a set of CpG targets that reliably differentiate AUD patients from controls and strongly correlate across brain tissue and more commonly collected tissue types (e.g., buccal cells).

Methods

Postmortem precuneus brain tissue samples were collected from 49 alcohol-dependent (AD) cases and 47 controls (sample I), and DNA was extracted from precuneus and putamen brain tissue and buccal cells in 24 postmortem subjects (sample II). Methylation levels were analyzed at over 450,000 CpG sites in both samples. CpGs that demonstrated significant methyla

SUBMITTER: Hagerty SL 

PROVIDER: S-EPMC5108727 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature