The Genome Conformation As an Integrator of Multi-Omic Data: The Example of Damage Spreading in Cancer.

ABSTRACT: Publicly available multi-omic databases, in particular if associated with medical annotations, are rich resources with the potential to lead a rapid transition from high-throughput molecular biology experiments to better clinical outcomes for patients. In this work, we propose a model for multi-omic data integration (i.e., genetic variations, gene expression, genome conformation, and epigenetic patterns), which exploits a multi-layer network approach to analyse, visualize, and obtain insights from such biological information, in order to use achieved results at a macroscopic level. Using this representation, we can describe how driver and passenger mutations accumulate during the development of diseases providing, for example, a tool able to characterize the evolution of cancer. Indeed, ou

SUBMITTER: Tordini F 

PROVIDER: S-EPMC5108817 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature