Protective Effects of Hydrogen Sulfide in the Ageing Kidney.

ABSTRACT: Aims. The study aimed to examine whether hydrogen sulfide (H₂S) generation changed in the kidney of the ageing mouse and its relationship with impaired kidney function. Results. H₂S levels in the plasma, urine, and kidney decreased significantly in ageing mice. The expression of two known H₂S-producing enzymes in kidney, cystathionine γ-lyase (CSE) and cystathionine-β-synthase (CBS), decreased significantly during ageing. Chronic H₂S donor (NaHS, 50 μmol/kg/day, 10 weeks) treatment could alleviate oxidative stress levels and renal tubular interstitial collagen deposition. These protective effects may relate to transcription factor Nrf2 activation and antioxidant proteins such as HO-1, SIRT1, SOD1, and SOD2 expre

SUBMITTER: Hou CL 

PROVIDER: S-EPMC5108860 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature