Discriminating cancer-related and cancer-unrelated chemoradiation-response genes for locally advanced rectal cancers.

ABSTRACT: For patients with locally advanced rectal cancer (LARC) treated with preoperation chemoradiation (pCRT), identifying differentially expressed (DE) genes between non-responders and responders is a common approach for investigating mechanisms of chemoradiation resistance. However, some of such DE genes might be irrelevant to cancer itself but simply reflect the pharmacokinetic differences of the normal tissues. In this study, we adopted the RankComp algorithm to identify DE genes for each of LARC sample compared with its own normal state. Then, we identified genes with significantly different deregulation frequencies between the non-responders and responders, defined as cancer-related pCRT-response genes. Pathway enrichment and protein-protein interaction analyses showed that these genes spe

SUBMITTER: Guo Y 

PROVIDER: S-EPMC5109405 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature