Comparative genomic analysis of the flagellin glycosylation island of the Gram-positive thermophile Geobacillus.

ABSTRACT:

Background

Protein glycosylation involves the post-translational attachment of sugar chains to target proteins and has been observed in all three domains of life. Post-translational glycosylation of flagellin, the main structural protein of the flagellum, is a common characteristic among many Gram-negative bacteria and Archaea. Several distinct functions have been ascribed to flagellin glycosylation, including stabilisation and maintenance of the flagellar filament, motility, surface recognition, adhesion, and virulence. However, little is known about this trait among Gram-positive bacteria.

Results

Using comparative genomic approaches the flagellin glycosylation loci of multiple strains of the Gram-positive thermophilic genus Geobacillus were identified and characterized. E

SUBMITTER: De Maayer P 

PROVIDER: S-EPMC5109656 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature