Unravelling the genomic architecture of bull fertility in Holstein cattle.

ABSTRACT:

Background

Fertility is considered an important economic trait in dairy cattle. Most studies have investigated cow fertility while bull fertility has received much less consideration. The main objective of this study was to perform a comprehensive genomic analysis in order to unravel the genomic architecture underlying sire fertility in Holstein dairy cattle. The analysis included the application of alternative genome-wide association mapping approaches and the subsequent use of diverse gene set enrichment tools.

Results

The association analyses identified at least eight genomic regions strongly associated with bull fertility. Most of these regions harbor genes, such as KAT8, CKB, TDRD9 and IGF1R, with functions related to sperm biology, including sperm development, motility

SUBMITTER: Han Y 

PROVIDER: S-EPMC5109745 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature