Diversity and distribution of alpha satellite DNA in the genome of an Old World monkey: Cercopithecus solatus.

ABSTRACT:

Background

Alpha satellite is the major repeated DNA element of primate centromeres. Evolution of these tandemly repeated sequences has led to the existence of numerous families of monomers exhibiting specific organizational patterns. The limited amount of information available in non-human primates is a restriction to the understanding of the evolutionary dynamics of alpha satellite DNA.

Results

We carried out the targeted high-throughput sequencing of alpha satellite monomers and dimers from the Cercopithecus solatus genome, an Old World monkey from the Cercopithecini tribe. Computational approaches were used to infer the existence of sequence families and to study how these families are organized with respect to each other. While previous studies had suggested that alpha

SUBMITTER: Cacheux L 

PROVIDER: S-EPMC5109768 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature