Identification of the stria medullaris thalami using diffusion tensor imaging.

ABSTRACT:

Background

Deep brain stimulation (DBS) via anatomical targeting of white matter tracts defined by diffusion tensor imaging (DTI) may be a useful tool in the treatment of pathologic neurophysiologic circuits implicated in certain disease states like treatment resistant depression (TRD). We sought to determine if DTI could be used to define the stria medullaris thalami (SM), the major afferent white matter pathway to the lateral habenula (LHb), a thalamic nucleus implicated in the pathophysiology of TRD.

Methods

Probabilistic DTI was performed on ten cerebral hemispheres in five patients who underwent preoperative MRI for DBS surgery. Manual identification of the LHb on axial T1 weighted MRI was used for the initial seed region for tractography. Variations in tractography dep

SUBMITTER: Kochanski RB 

PROVIDER: S-EPMC5109849 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature