Failure to mobilize cognitive control for challenging tasks correlates with symptom severity in schizophrenia.

ABSTRACT: Deficits in the adaptive, flexible control of behavior contribute to the clinical manifestations of schizophrenia. We used functional MRI and an antisaccade paradigm to examine the neural correlates of cognitive control deficits and their relations to symptom severity. Thirty-three chronic medicated outpatients with schizophrenia and 31 healthy controls performed an antisaccade paradigm. We examined differences in recruitment of the cognitive control network and task performance for Hard (high control) versus Easy (low control) antisaccade trials within and between groups. We focused on the key regions involved in 'top-down' control of ocular motor structures - dorsal anterior cingulate cortex, dorsolateral and ventrolateral prefrontal cortex. In patients, we examined whether difficulty im

SUBMITTER: Baran B 

PROVIDER: S-EPMC5109850 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature