Probing the PI3K/Akt/mTor pathway using ³¹P-NMR spectroscopy: routes to glycogen synthase kinase 3.

ABSTRACT: Akt is an intracellular signalling pathway that serves as an essential link between cell surface receptors and cellular processes including proliferation, development and survival. The pathway has many downstream targets including glycogen synthase kinase3 which is a major regulatory kinase for cell cycle transit as well as controlling glycogen synthase activity. The Akt pathway is frequently up-regulated in cancer due to overexpression of receptors such as the epidermal growth factor receptor, or mutation of signalling pathway kinases resulting in inappropriate survival and proliferation. Consequently anticancer drugs have been developed that target this pathway. MDA-MB-468 breast and HCT8 colorectal cancer cells were treated with inhibitors including LY294002, MK2206, rapamycin, AZD8055

SUBMITTER: Phyu SM 

PROVIDER: S-EPMC5109916 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature