Differential abnormalities of functional connectivity of the amygdala and hippocampus in unipolar and bipolar affective disorders.

ABSTRACT:

Objective

The amygdala and hippocampus - two structures intimately associated with mood and cognition - have been reported to exhibit altered neural activity or volume in affective disorders. We hypothesized the amygdala and hippocampus would show altered and differential patterns of connectivity in patients with bipolar (BPs) and unipolar (UPs) disorder compared to healthy volunteers.

Method

Thirty BPs, 34 UPs, and 66 healthy volunteers were imaged using F-18-fluorodeoxyglucose and positron emission tomography while performing an auditory continuous performance task (CPT). Normalized mean activity of the amygdala and hippocampus was correlated with the rest of the brain.

Results

In BPs, the amygdalae displayed exaggerated positive metabolic correlations with prefront

SUBMITTER: Benson BE 

PROVIDER: S-EPMC5109926 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature