Heterogeneous cortical atrophy patterns in MCI not captured by conventional diagnostic criteria.

ABSTRACT:

Objective

We investigated differences in regional cortical thickness between previously identified empirically derived mild cognitive impairment (MCI) subtypes (amnestic MCI, dysnomic MCI, dysexecutive/mixed MCI, and cluster-derived normal) in order to determine whether these cognitive subtypes would show different patterns of cortical atrophy.

Methods

Participants were 485 individuals diagnosed with MCI and 178 cognitively normal individuals from the Alzheimer's Disease Neuroimaging Initiative. Cortical thickness estimates were computed for 32 regions of interest per hemisphere. Statistical group maps compared each MCI subtype to cognitively normal participants and to one another.

Results

The pattern of cortical thinning observed in each MCI subtype corresponded to t

SUBMITTER: Edmonds EC 

PROVIDER: S-EPMC5109943 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature