Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study.

ABSTRACT:

Objective

To identify a cortical signature pattern of cortical thinning in familial Alzheimer disease (FAD) and assess its utility in detecting and tracking presymptomatic neurodegeneration.

Methods

We recruited 43 FAD mutation carriers-36 PSEN1, 7 APP (20 symptomatic, 23 presymptomatic)-and 42 healthy controls to a longitudinal clinical and MRI study. T1-weighted MRI scans were acquired at baseline in all participants; 55 individuals (33 mutation carriers; 22 controls) had multiple (mean 2.9) follow-up scans approximately annually. Cortical thickness was measured using FreeSurfer. A cortical thinning signature was identified from symptomatic FAD participants. We then examined cortical thickness changes in this signature region in presymptomatic carriers and assessed associa

SUBMITTER: Weston PS 

PROVIDER: S-EPMC5109950 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature