Nucleus prepositus hypoglossi lesions produce a unique ocular motor syndrome.

ABSTRACT:

Objective

To describe the ocular motor abnormalities in 9 patients with a lesion involving the nucleus prepositus hypoglossi (NPH), a key constituent of a vestibular-cerebellar-brainstem neural network that ensures that the eyes are held steady in all positions of gaze.

Methods

We recorded eye movements, including the vestibulo-ocular reflex during head impulses, in patients with vertigo and a lesion involving the NPH.

Results

Our patients showed an ipsilesional-beating spontaneous nystagmus, horizontal gaze-evoked nystagmus more intense on looking toward the ipsilesional side, impaired pursuit more to the ipsilesional side, central patterns of head-shaking nystagmus, contralateral eye deviation, and decreased vestibulo-ocular reflex gain during contralesionally direc

SUBMITTER: Kim SH 

PROVIDER: S-EPMC5109954 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature