Structural basis of nonribosomal peptide macrocyclization in fungi.

ABSTRACT: Nonribosomal peptide synthetases (NRPSs) in fungi biosynthesize important pharmaceutical compounds, including penicillin, cyclosporine and echinocandin. To understand the fungal strategy of forging the macrocyclic peptide linkage, we determined the crystal structures of the terminal condensation-like (C_T) domain and the holo thiolation (T)-C_T complex of Penicillium aethiopicum TqaA. The first, to our knowledge, structural depiction of the terminal module in a fungal NRPS provides a molecular blueprint for generating new macrocyclic peptide natural products.

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5110376 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature